{"id":53,"date":"2026-06-02T15:10:25","date_gmt":"2026-06-02T13:10:25","guid":{"rendered":"https:\/\/perso.uclouvain.be\/corentin.claeys\/?page_id=53"},"modified":"2026-07-17T14:42:09","modified_gmt":"2026-07-17T12:42:09","slug":"home","status":"publish","type":"page","link":"https:\/\/perso.uclouvain.be\/corentin.claeys\/","title":{"rendered":"Home"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"53\" class=\"elementor elementor-53\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f3da6ba elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f3da6ba\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b020d92\" data-id=\"b020d92\" 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1000 1000\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M696 533C708 521 713 504 713 487 713 471 708 454 696 446L400 146C388 133 375 125 354 125 338 125 325 129 313 142 300 154 292 171 292 187 292 204 296 221 308 233L563 492 304 771C292 783 288 800 288 817 288 833 296 850 308 863 321 871 338 875 354 875 371 875 388 867 400 854L696 533Z\"><\/path><\/svg>\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"swiper-pagination\"><\/div>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-64c26c4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"64c26c4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b15aba1\" data-id=\"b15aba1\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-93bee1d elementor-widget elementor-widget-heading\" data-id=\"93bee1d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Welcome to the Claeys Bouuaert Lab<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ac593f elementor-widget elementor-widget-text-editor\" data-id=\"9ac593f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Our laboratory is interested in the molecular processes that impact the inheritance of genetic material, in particular in the context of meiosis &#8211; the cellular program that generates reproductive cells. We use biochemistry and molecular genetics approaches with the model organism Saccharomyces cerevisiae to work out the intricate mechanisms of DNA recombination that are implicated in the formation of gametes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b199405 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b199405\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-55c5cb5\" data-id=\"55c5cb5\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-027d71d elementor-widget elementor-widget-heading\" data-id=\"027d71d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Research highlights<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-cdf96ae elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cdf96ae\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-325b04c\" data-id=\"325b04c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-940cfd4 elementor-widget elementor-widget-text-editor\" data-id=\"940cfd4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><strong>Dimerization of the <em>S. cerevisiae<\/em> Spo11 core complex<\/strong><b>.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5955318 elementor-widget elementor-widget-image\" data-id=\"5955318\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"943\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-1024x943.jpg\" class=\"attachment-large size-large wp-image-8969\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-1024x943.jpg 1024w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-300x276.jpg 300w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-768x707.jpg 768w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-1536x1415.jpg 1536w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/06\/Figure-1-Intro-reduced-2048x1887.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-63ada9e\" data-id=\"63ada9e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-34f2520 elementor-widget elementor-widget-text-editor\" data-id=\"34f2520\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By A\u00eft Bella H., Survi M., Urdiain-Arraiza J., Daga D., Subramanian V.V., Hochwagen A., Claeys Bouuaert C. <em>bioRxiv<\/em>, 2026.<\/p><p>Yeast Spo11 forms a complex with Rec102, Rec104 and Ski8 that must dimerize to enable DNA cleavage. We show that the Spo11 complex dimerizes transiently on DNA, through Spo11-Spo11 interactions and previously unknown interactions between Rec102 and Ski8, providing new insights into how these proteins collaborate to initiate meiotic recombination.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-92cf01d elementor-align-center elementor-widget elementor-widget-button\" data-id=\"92cf01d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.biorxiv.org\/content\/10.64898\/2026.01.16.699991v1\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb41245 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"eb41245\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n<hr class=\"e-divider-base\" data-interaction-id=\"b46906d\"   \/>\n\t\t\t\t\t\n<hr class=\"e-divider-base\" data-interaction-id=\"76d8770\"   \/>\n\t\t\t\t\t\n<hr class=\"e-divider-base\" data-interaction-id=\"f03b00a\"   \/>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-0d998ec elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"0d998ec\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-26fcb4d\" data-id=\"26fcb4d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a1c6337 elementor-widget elementor-widget-text-editor\" data-id=\"a1c6337\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><b>Recruitment of Mre11 to recombination sites during meiosis.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c8681a elementor-widget elementor-widget-image\" data-id=\"0c8681a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"822\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-1024x822.png\" class=\"attachment-large size-large wp-image-8333\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-1024x822.png 1024w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-300x241.png 300w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-768x617.png 768w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-1536x1234.png 1536w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2025\/07\/Figure-2-scaled-1-2048x1645.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-b740a04\" data-id=\"b740a04\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f72e37b elementor-widget elementor-widget-text-editor\" data-id=\"f72e37b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By Priyadarshini P., Survi M., El Yazidi Mouloud W., Bohn R., Ballet S., Hunter N., Volkov A.N., Claeys Bouuaert C. <em>Nature Communications<\/em>, 2026.<\/p><p>Mre11 is required for the formation of double-strand breaks by Spo11, and their ensuing repair by recombination. Here, we show that chromatin association of Mre11 during meiosis involves biomolecular condensation, direct binding to Mer2 and SUMO-SIM interactions, revealing a combination of mechanisms that allows its recruitment\u00a0to future recombination sites.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6562770 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"6562770\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.nature.com\/articles\/s41467-026-71310-5\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-e6391d1 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e6391d1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-801f142 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"801f142\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a76351e\" data-id=\"a76351e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-42b9885 elementor-widget elementor-widget-text-editor\" data-id=\"42b9885\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><b>SPO11 dimers are sufficient to catalyse DNA double-strand breaks in vitro.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ce8eab elementor-widget elementor-widget-image\" data-id=\"9ce8eab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1024\" height=\"539\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-1024x539.jpg\" class=\"attachment-large size-large wp-image-7703\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-1024x539.jpg 1024w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-300x158.jpg 300w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-768x404.jpg 768w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-1536x808.jpg 1536w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2024\/11\/Figure-1-Reconstitution-scaled-1-2048x1078.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-ec1ca8f\" data-id=\"ec1ca8f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ec66d42 elementor-widget elementor-widget-text-editor\" data-id=\"ec66d42\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By Oger C., Claeys Bouuaert C. <em>Nature<\/em>, 2025.<\/p><p>SPO11 initiates meiotic recombination by inducing DNA double-strand breaks, but this catalytic activity had never been reconstituted <em>in vitro<\/em>. Here, we report the reconstitution of the DNA cleavage activity of mouse SPO11, highlighting the key role of SPO11 dimerization in controlling DNA cleavage.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b6dfe1 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"7b6dfe1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.nature.com\/articles\/s41586-024-08574-8\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-4b4d221 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"4b4d221\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e976f33 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e976f33\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-afa1202\" data-id=\"afa1202\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8bf5a05 elementor-widget elementor-widget-text-editor\" data-id=\"8bf5a05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><b>Evolutionary conservation of the structure and function of meiotic Rec114-Mei4 and Mer2 complexes.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f28181 elementor-widget elementor-widget-image\" data-id=\"6f28181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"508\" height=\"284\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2022\/12\/Daccache-Figure-1.jpg\" class=\"attachment-large size-large wp-image-5303\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2022\/12\/Daccache-Figure-1.jpg 508w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2022\/12\/Daccache-Figure-1-300x168.jpg 300w\" sizes=\"(max-width: 508px) 100vw, 508px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-98461cc\" data-id=\"98461cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-36bcbd6 elementor-widget elementor-widget-text-editor\" data-id=\"36bcbd6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By Daccache D., De Jonge E., Liloku P., Mechleb K., Haddad M., Corthaut S., Sterckx Y.G., Volkov A.N., Claeys Bouuaert C. <em>Genes &amp; Developement<\/em>, 2023.<\/p><p style=\"font-weight: 400;\">Rec114, Mei4 and Mer2 (RMM) have a central role in organizing the meiotic double-strand-break machinery. This article presents a structural and functional analysis of RMM proteins from yeast and other organisms, revealing deep evolutionary conservation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cac6fae elementor-align-center elementor-widget elementor-widget-button\" data-id=\"cac6fae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/genesdev.cshlp.org\/content\/37\/11-12\/535.long\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-e9a9281 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e9a9281\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-f7af975 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f7af975\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-1fa2739\" data-id=\"1fa2739\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3cd34ed elementor-widget elementor-widget-text-editor\" data-id=\"3cd34ed\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: center;\"><b>DNA-driven condensation assembles the meiotic DNA break machinery.<\/b><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d6358bf elementor-widget elementor-widget-image\" data-id=\"d6358bf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"470\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-1024x470.jpg\" class=\"attachment-large size-large wp-image-8994\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-1024x470.jpg 1024w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-300x138.jpg 300w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-768x352.jpg 768w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-1536x704.jpg 1536w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2026\/07\/Claeys-Bouuaert-Figure-2-2048x939.jpg 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-81af04d\" data-id=\"81af04d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b6b4b23 elementor-widget elementor-widget-text-editor\" data-id=\"b6b4b23\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By Claeys Bouuaert, C., Pu S., Wang J., Oger C., Daccache D., Xie W., Patel D.J., Keeney S. <em>Nature<\/em>, 2021.<\/p><p>Meiotic DNA double-strand break formation depends on Rec114, Mei4 and Mer2. Here, we show that these proteins undergo DNA-dependent condensation, suggesting a new mechanism whereby they organize the meiotic DNA double-strand break machinery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0b872a elementor-align-center elementor-widget elementor-widget-button\" data-id=\"a0b872a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/www.nature.com\/articles\/s41586-021-03374-w\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Read the paper<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1b3bbc8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1b3bbc8\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2a91576\" data-id=\"2a91576\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-43e2676 elementor-widget elementor-widget-heading\" data-id=\"43e2676\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Funding<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-462da23 elementor-section-content-middle elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"462da23\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2de5d03\" data-id=\"2de5d03\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ad9a6df elementor-widget elementor-widget-image\" data-id=\"ad9a6df\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"329\" height=\"323\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/ERC-Logo.jpg\" class=\"attachment-large size-large wp-image-1273\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/ERC-Logo.jpg 329w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/ERC-Logo-300x295.jpg 300w\" sizes=\"(max-width: 329px) 100vw, 329px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-45b187a\" data-id=\"45b187a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-97fa9c2 elementor-widget elementor-widget-image\" data-id=\"97fa9c2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"440\" height=\"279\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-FNRS.png\" class=\"attachment-large size-large wp-image-1283\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-FNRS.png 440w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-FNRS-300x190.png 300w\" sizes=\"(max-width: 440px) 100vw, 440px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-inner-column elementor-element elementor-element-2baf4e3\" data-id=\"2baf4e3\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a82ad7e elementor-widget elementor-widget-image\" data-id=\"a82ad7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"900\" height=\"500\" src=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-UCL.png\" class=\"attachment-large size-large wp-image-3233\" alt=\"\" srcset=\"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-UCL.png 900w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-UCL-300x167.png 300w, https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-content\/uploads\/2021\/12\/Logo-UCL-768x427.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Welcome to the Claeys Bouuaert Lab Our laboratory is interested in the molecular processes that impact the inheritance of genetic material, in particular in the context of meiosis &#8211; the cellular program that generates reproductive cells. We use biochemistry and molecular genetics approaches with the model organism Saccharomyces cerevisiae to work out the intricate mechanisms [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ocean_front_end_style_editor":"no","ocean_post_layout":"full-screen","ocean_both_sidebars_style":"","ocean_both_sidebars_content_width":0,"ocean_both_sidebars_sidebars_width":0,"ocean_sidebar":"0","ocean_second_sidebar":"0","ocean_disable_margins":"enable","ocean_add_body_class":"","ocean_shortcode_before_top_bar":"","ocean_shortcode_after_top_bar":"","ocean_shortcode_before_header":"","ocean_shortcode_after_header":"","ocean_has_shortcode":"","ocean_shortcode_after_title":"","ocean_shortcode_before_footer_widgets":"","ocean_shortcode_after_footer_widgets":"","ocean_shortcode_before_footer_bottom":"","ocean_shortcode_after_footer_bottom":"","ocean_display_top_bar":"off","ocean_display_header":"default","ocean_header_style":"","ocean_center_header_left_menu":"0","ocean_custom_header_template":"0","ocean_custom_logo":8193,"ocean_custom_retina_logo":0,"ocean_custom_logo_max_width":0,"ocean_custom_logo_tablet_max_width":0,"ocean_custom_logo_mobile_max_width":0,"ocean_custom_logo_max_height":0,"ocean_custom_logo_tablet_max_height":0,"ocean_custom_logo_mobile_max_height":0,"ocean_header_custom_menu":"0","ocean_menu_typo_font_family":"0","ocean_menu_typo_font_subset":"","ocean_menu_typo_font_size":0,"ocean_menu_typo_font_size_tablet":0,"ocean_menu_typo_font_size_mobile":0,"ocean_menu_typo_font_size_unit":"px","ocean_menu_typo_font_weight":"","ocean_menu_typo_font_weight_tablet":"","ocean_menu_typo_font_weight_mobile":"","ocean_menu_typo_transform":"","ocean_menu_typo_transform_tablet":"","ocean_menu_typo_transform_mobile":"","ocean_menu_typo_line_height":0,"ocean_menu_typo_line_height_tablet":0,"ocean_menu_typo_line_height_mobile":0,"ocean_menu_typo_line_height_unit":"","ocean_menu_typo_spacing":0,"ocean_menu_typo_spacing_tablet":0,"ocean_menu_typo_spacing_mobile":0,"ocean_menu_typo_spacing_unit":"","ocean_menu_link_color":"","ocean_menu_link_color_hover":"","ocean_menu_link_color_active":"","ocean_menu_link_background":"","ocean_menu_link_hover_background":"","ocean_menu_link_active_background":"","ocean_menu_social_links_bg":"","ocean_menu_social_hover_links_bg":"","ocean_menu_social_links_color":"","ocean_menu_social_hover_links_color":"","ocean_disable_title":"on","ocean_disable_heading":"default","ocean_post_title":"","ocean_post_subheading":"","ocean_post_title_style":"","ocean_post_title_background_color":"","ocean_post_title_background":0,"ocean_post_title_bg_image_position":"","ocean_post_title_bg_image_attachment":"","ocean_post_title_bg_image_repeat":"","ocean_post_title_bg_image_size":"","ocean_post_title_height":0,"ocean_post_title_bg_overlay":0.5,"ocean_post_title_bg_overlay_color":"","ocean_disable_breadcrumbs":"default","ocean_breadcrumbs_color":"","ocean_breadcrumbs_separator_color":"","ocean_breadcrumbs_links_color":"","ocean_breadcrumbs_links_hover_color":"","ocean_display_footer_widgets":"off","ocean_display_footer_bottom":"off","ocean_custom_footer_template":"0","footnotes":""},"class_list":["post-53","page","type-page","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/pages\/53","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/comments?post=53"}],"version-history":[{"count":23,"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/pages\/53\/revisions"}],"predecessor-version":[{"id":9007,"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/pages\/53\/revisions\/9007"}],"wp:attachment":[{"href":"https:\/\/perso.uclouvain.be\/corentin.claeys\/wp-json\/wp\/v2\/media?parent=53"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}