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Tuesday January 13th,
2009 from 14:00 to 19:00
Location: Auditoire Maisin, UCL Brussels
Program:
14:00 René van Rijn, Free University Medical Center, Amsterdam
15:00 David Zee,The Johns Hopkins Hospital, Baltimore, USA
16:00 Coffee break
16:30 Demet Yüksel, St Luc Hospital and UCL.
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Detailed program: 14:00 René van Rijn, Free University Medical Center, Amsterdam, The Netherlands “Quality control in strabismic surgery. Predictability of strabismus surgery in children with developmental delay".
Abstract:
Two years
ago, a web-bases registration system for quality control for cataract surgery
was introduced in The Netherlands. In this system, each cataract surgeon can register
his/her pre- per- and postoperative findings of each cataract operation and
compare these findings with the (anonymized) mean of all other participants. This allows
each cataract surgeon to gain insight in his/her own results compared to the
nationwide mean. This system comprises an extension of the stand-alone cataract
registration system which was developed by the late prof Breebaart. Because of
the success of this system, it has now been extended to include strabismus
surgery. The properties of this system will be discussed.
Children with developmental disorders and/or
psychomotoric delay may respond differently to strabismus surgery than children
who develop normally, but the literature is conflicting. In this talk we demonstrate that Rc-surgery in children with developmental
disorders and/or psychomotoric disorders should be dosed lower than usual, RcRs-surgery
may be dosed normally.
15:00 David Zee,
The Johns Hopkins Hospital, Baltimore, USA
“The pathophysiology of saccadic oscillations.”
Abstract:
Saccadic oscillations threaten clear vision by causing image motion on the retina.
They are either purely horizontal (ocular flutter) or multidimensional
(opsoclonus). We propose that ion channel dysfunction in the burst cell
membrane is the underlying abnormality. We have tested this hypothesis
by simulating a neuromimetic computational model of the burst neurons.
This biologically-realistic model mimics the physiological properties
and anatomical connections in the brainstem saccade generator. A
rebound firing after sustained inhibition, called post-inhibitory
rebound (PIR), and reciprocal inhibition between premotor saccadic
burst neurons are the key features of this conceptual scheme. PIR and
reciprocal inhibition make the circuits that generate the saccadic
burst inherently unstable, and can lead to oscillations unless
stabilized by external inhibition. Our simulations suggest that
alterations in membrane properties which lead to an increase in PIR, a
reduction in external glycinergic inhibition, or both, can cause
saccadic oscillations.
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16:30 Demet Yüksel,
St Luc Hospital and UCL
“How to achieve binocular control in Duane Retraction Syndrome?”
Abstract:
Fundamental questions about the binocular coordination of saccades
have been raised by studying DRS. The importance of performing
recordings with high resolution techniques and simultaneous recording
of the two eyes in different viewing conditions will be emphasized.
Indeed, it allows quantitative analysis of the results and gives
insight on how the visual sensory information received by one eye is
processed and transferred to the non-viewing eye. In case of binocular
viewing, it is of main interest to control which eye is the dominant
eye. For biomechanical purpose, saccades should be separately analyzed
in centrifugal and centripetal direction in both directions of gaze.
This approach should be considered in all studies dealing with
strabismus. Finally, modeling DRS allows quantification of the residual
innervation of the abducens nerve and the amount of supply from the
oculomotor nerve.
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