Preprints
2026 Cohesin–axis interaction via a conserved Red1 motif promotes domain-specific DSB formation and Mek1 activation. bioRxiv. Rajalingam A., Tsuruta Y., Roy T., Urdiain-Arraiza J, Alnaser H.F., Hiraga S., Claeys Bouuaert C., Murakami H.
2026 Dimerization of the S. cerevisiae Spo11 core complex. bioRxiv. Aït Bella H., Survi M., Urdiain-Arraiza J., Daga D., Subramanian VV., Hochwagen A., Claeys Bouuaert C.
2026 Insights into the recruitment of the H3K4me3 reader Spp1 by the meiotic double-strand break protein Mer2. bioRvix. Liloku P., Alvarez-Melo D., Gisbert V.G., Mannaert S., Mechleb K., Derclaye S., Alsteens D., Volkov A.N., Sterckx Y.G.J., Claeys Bouuaert C.
Publications
2026 Recruitment of Mre11 to recombination sites during meiosis. Nature Communications. Priyadarshini P., Survi M., El Yazidi Mouloud W., Bohn R., Ballet S., Hunter N., Volkov A.N., Claeys Bouuaert C.
2025 In vitro reconstitution of SPO11-mediated DNA cleavage sheds new light on the initiation of meiotic recombination. DNA Cell Biol. Oger C., Claeys Bouuaert C.
2025 SPO11 dimers are sufficient to catalyse DNA double-strand breaks. Nature. Oger C., Claeys Bouuaert C.
2024 Cryo-EM structure of the Spo11 core complex bound to DNA. Nature Structural & Molecular Biology. Yu Y., Wang J., Liu K., Zheng Z., Arter M., Claeys Bouuaert C., Pu S., Patel D.J., Keeney S.
2023 Evolutionary conservation of the structure and function of meiotic Rec114-Mei4 and Mer2 complexes. Genes & Development. Daccache D., De Jonge E., Liloku P., Mechleb K., Haddad M., Corthaut S., Sterckx Y.G., Volkov A.N., Claeys Bouuaert C.
2021 DNA-driven condensation assembles the meiotic DNA break machinery. Nature. Claeys Bouuaert, C., Pu S., Wang J., Oger C., Daccache D., Xie W., Patel D.J., Keeney S.
2021 Mechanism and control of meiotic DNA double-strand break formation in S. cerevisiae. Frontiers Cell Dev Biol. Yadav V.K., Claeys Bouuaert C.
2021 Concerted cutting by Spo11 illuminates the mechanism of meiotic DNA break formation. Nature. Johnson D., Crawford M., Cooper T., Claeys Bouuaert C., Keeney S., Llorente B., Garcia V., Neale M.J.
2021 Structural and functional characterization of the Spo11 core complex. Nature Structural & Molecular Biology. Claeys Bouuaert C., Tischfield S.E., Pu S., Mimitou E.P., Arias-Palomo E., Berger J.M., Keeney S.
2017 Distinct DNA-binding surfaces in the ATPase and linker domains of MutLgamma determine its substrate specificities and exert separable functions in meiotic recombination and mismatch repair. PLoS Genetics. Claeys Bouuaert, C., and Keeney, S
2017 rahu is a mutant allele of Dnmt3c, encoding a DNA methyltransferase homolog required for meiosis and transposon repression in the mouse male germline. PLoS Genetics. Jain, D., Meydan, C., Lange, J., Claeys Bouuaert, C., Mason, C.E., Anderson, K.V., and Keeney, S.
2017 A single active site in the mariner transposase cleaves DNA strands of opposite polarity. Nucleic Acids Research. Claeys Bouuaert, C., and Chalmers, R.
2016 Breaking DNA. Science. Claeys Bouuaert, C., and Keeney, S.
2014 One to rule them all: A highly conserved motif in mariner transposase controls multiple steps of transposition. Mobile Genetic Elements. Claeys Bouuaert, C., Tellier, M., and Chalmers, R.
2014 Crosstalk between transposase subunits during cleavage of the mariner transposon. Nucleic Acids Research. Claeys Bouuaert, C., Walker, N., Liu, D., and Chalmers, R.
2013 The autoregulation of a eukaryotic DNA transposon. Elife. Claeys Bouuaert, C., Lipkow, K., Andrews, S.S., Liu, D., and Chalmers, R.
2013 Hsmar1 transposition is sensitive to the topology of the transposon donor and the target. PLoS One. Claeys Bouuaert, C., and Chalmers, R.
2011 A simple topological filter in a eukaryotic transposon as a mechanism to suppress genome instability. Molecular and Cellular Biology. Claeys Bouuaert, C., Liu, D., and Chalmers, R.
2010 Transposition of the human Hsmar1 transposon: rate-limiting steps and the importance of the flanking TA dinucleotide in second strand cleavage. Nucleic Acids Research. Claeys Bouuaert, C., and Chalmers, R.
2010 Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons. Genetica. Claeys Bouuaert, C., and Chalmers, R.M.