Georges Bastin

Department of Mathematical Engineering
Center for Systems Engineering and Applied Mechanics (CESAME)
Université catholique de Louvain

4, Avenue G. Lemaitre, 1348 Louvain-la-Neuve, Belgium

Tel : +32 10 47 80 38

Email : Georges.Bastin [at]


PhD Supervision


Full list of publications of G.Bastin

Books and lecture notes

On line estimation and adaptive control of bioreactors (with D. Dochain) [zip]

Lectures on mathematical modelling of biological systems [pdf]

"Lecture notes on modelling and control of mass balance systems"
[pdf] in " Advances in the Control of Nonlinear Systems ", Lecture Notes in Control and Information Sciences n° 264, Springer-Verlag, 2001, pp. 229-252

"Using hyperbolic systems of balance laws for modeling, control and stability analysis of physical networks", Lecture notes for the Conference on ”Control of Physical Systems and Partial Differential Equations”, Institut Henri Poincaré, Paris, June 16-20, 2008, and for for the Pre-Congress Workshop on Complex Embedded and Networked Control Systems, 17th IFAC World Congress, Seoul, Korea, July 2008. [pdf]

"Modélisation et analyse des systèmes dynamiques" Lectures notes Louvain School of Engineering. [pdf]

"Stability and Boundary Stabilization of 1-D Hyperbolic Systems", (with J-M. Coron), Birkhauser 2016, [preprint]

Recent articles

G. Bastin and J-M. Coron, "A quadratic Lyapunov function for hyperbolic density-velocity systems with nonuniform steady states", submitted for publication. [preprint]

L. Haustenne, G. Bastin, P. Hols, L. Fontaine, "Modelling of the ComRS signalling pathway reveals the limiting factors controlling competence in Streptococcus thermophilus", Frontiers in Microbiology, Vol.6, 2015, Article 1413. [pdf]

S. Afonso Fernandes, G.Bastin, M. Jolicoeur, A. Vande Wouwer, "Dynamic metabolic flux analysis using a convex analysis approach: application to hybridoma cell cultures in perfusion", Biotechnology and Bioengineering, Vol. 113(5), 2016, pp. 1102-1112. [pdf]

L. Haustenne, G. Bastin, J-M. Coron, L. Fontaine, P. Hols, "On stability analysis of genetic regulatory networks represented by delay-differential equations", IFAC PapersOnLine 48-1, 2015, pp. 453-457. [pdf]

J-M. Coron and G. Bastin, "Dissipative boundary conditions for one-dimensional quasi-linear hyperbolic systems: Lyapunov stability for the C1-norm", SIAM Journal of Control and Optimization, Vol. 53(3), 2015, pp. 1464 - 1483.

G.Bastin, J-M. Coron and S-O. Tamasoiu, "Stability of linear density-flow hyperbolic systems under PI boundary control". Automatica, Vol.53, 2015, pp. 37 - 42. [pdf]

G. Bastin and I. Cassiers, "Green growth or low growth: Modelling the balanced transition to a sustainable economy". Report.

G. Bastin and I. Cassiers, "Modelling the balanced transition to a sustainable economy", IRES Discussion Paper 2013-14, Université catholique de Louvain.

G. Bastin, J-M. Coron, B. d'Andréa-Novel, P. Suvarov, A. Vande Wouwer, A. Kienle, "Stability of switched hyperbolic systems: the example of SMB chromatography". [preprint]

J-M. Coron, R. Vazquez, M. Krstic, G. Bastin, "Local exponential H2 stabilization of 2x2 quasilinear hyperbolic systems using backstepping", SIAM Journal of Control and Optimization, Vol.51(3), 2013, pp. 2005 - 2035. [pdf]

F. Zamorano, A. Vande Wouwer, R.M. Jungers, G. Bastin, "Dynamic metabolic models of CHO cell cultures through minimal sets of elementary flux modes", Journal of Biotechnology, Vol.164(3), 2013, pp.409-422. [pdf]

A. Diagne, G. Bastin, J-M Coron, "Lyapunov exponential stability of linear hyperbolic systems of balance laws », Automatica, Vol. 48(1), 2012, pp. 109 - 114.

G. Bastin and J-M. Coron, "On boundary feedback stabilization of non-uniform linear 2 × 2 hyperbolic systems over a bounded interval", Systems and Control Letters, Vol. 60(11), 2011, pp. 900 - 906. [pdf]

R.M. Jungers, F. Zamorano, V.D. Blondel, A. Vande Wouwer, G. Bastin, "Fast computation of minimal elementary decompositions of metabolic flux vectors", Automatica, Special issue on Systems Biology, Vol. 47(7), 2011, pp. 1255 - 1259. [pdf]

F. Zamorano, A. Vande Wouwer, G. Bastin, "A detailed metabolic flux analysis of an undetermined network of CHO cells", Journal of Biotechnology, Vol.150(4), 2010, pp. 497 - 508. [pdf]

G. Bastin, J-M. Coron, B. d'Andréa-Novel, "On Lyapunov stability of linearised Saint-Venant equations for a sloping channel", Networks and Heterogeneous Media, Vol. 4(2), 2009, pp. 177 - 187. [pdf]

N. Bedjaoui, E. Weyer and G. Bastin, "Methods for the localization of a leak in open water channels", Networks and Heterogeneous Media, Vol. 4(2), 2009, pp. 189 - 210. [pdf]

G. Bastin, A.M. Bayen, C. D'Apice, X. Litrico, B. Piccoli, "Open problems and research perspectives for irrigation channels", Networks and Heterogeneous Media, Vol.4(2), 2009, pp. i-v. [pdf]

G. Bastin, "Quantitative analysis of metabolic networks and design of minimal bioreaction models: a brief tutorial", ARIMA, Revue Africaine de la Recherche en Informatique et Mathématiques Appliquées, Vol.9(1), pp. 41 - 55, 2008. [pdf]

G. Bastin, D. Nesic, Y. Tan, I. Mareels, "On extremum seeking in bioprocesses with multivalued cost functions", Biotechnology Progress, Vol. 25(3), 2009, pp. 683 - 689. [pdf]

J-M. Coron, G. Bastin, B. d'Andréa-Novel, "Dissipative boundary conditions for one-dimensional nonlinear hyperbolic systems", SIAM Journal on Control and Optimization, Vol. 47(3), 2008, pp. 1460 - 1498. [pdf]

G. Bastin, B. Haut, J-M. Coron, B. d'Andréa-Novel, "Lyapunov stability analysis of networks of scalar conservation laws ", Networks and Heterogeneous Media, Vol. 2(4), pp. 749 - 757, 2007. [pdf]

V. Dos Santos, G. Bastin, J-M. Coron, B. d'Andréa-Novel, "Boundary control with integral action for hyperbolic systems of conservation laws : stability and experiments ", Automatica, Vol. 44(5), 2008, pp. 1310 - 1318. [pdf]

C. Prieur, J. Winkin, G. Bastin, "Robust boundary control of systems of conservation laws",  Mathematics of Control, Signals and Systems, Vol. 20, pp. 173 - 197, 2008. [pdf]

B. Haut, G. Bastin, P. Van Dooren, "Maximal stability region of a perturbed nonnegative matrix", International Journal of Robust and Nonlinear Control, Vol. 19(3), pp. 364 - 376, 2009. [pdf]

G. Bastin, "Sur la modélisation et le contrôle des réseaux dynamiques conservatifs", Revue E-STA, Special CIFA 2006, Vol. 3(2), 2007. [pdf]

B. Haut and G. Bastin, "A second order model of road junctions in fluid models of traffic networks", Networks and Heterogeneous Media, Vol. 2(2), pp. 227 - 253, 2007. [pdf]

A. Provost, G. Bastin, S. Agathos, Y-J. Schneider "Metabolic design of macroscopic bioreaction models : Application to Chinese hamster ovary cells", Bioprocess and Biosystems Engineering, Vol. 29(5-6), 2006, pp. 349-366. [pdf]

J-B. Coulaud, G. Campion, G. Bastin, M. Dewan, "Stability analysis of a vision-based control design for an autonomous mobile robot", IEEE Transactions on Robotics, Vol. 22(9), 2006, pp. 1062 - 1069. [pdf]

J-M. Coron, B. d'Andréa-Novel, G. Bastin, "A strict Lyapunov function for boundary control of hyperbolic systems of conservation laws", IEEE Transactions on Automatic Control, Vol. 52(1), 2007, pp. 2 - 11. [pdf]

G. Bastin and V. Guffens, "Congestion control in compartmental network systems", Systems and Control Letters, Vol. 55(8), 2006, pp. 689 - 696. [pdf]

F. Grognard, Y. Chitour, G. Bastin, "Equilibria and stability analysis of a branched metabolic network with feedback inhibition", Network and Heterogeneous Media, Vol. 1(1), 2006, pp. 219 - 239. [pdf]

O. Bernard and G. Bastin, "Identification of reaction networks for bioprocesses : determination of a partially unknown pseudo-stoichiometric matrix", Bioprocess and Biosystems Engineering, Vol. 27(5), 2005, pp. 293 - 301. [pdf]

C. Dal Cin, L. Moens, P. Dierickx, G. Bastin, Y. Zech, "An integrated approach for real-time flood-map forecasting on the Belgian Meuse river", Natural Hazards, Vol. 36(1-2), 2005, pp. 237 - 256. [pdf]

O. Bernard, G. Bastin, "On the estimation of the pseudo-stoichiometric matrix for macroscopic mass balance modelling of biotechnological processes", Mathematical Biosciences, Vol. 193, 2005, pp. 51 - 77. [pdf]

A. Provost, G. Bastin, "Dynamical metabolic modelling under the balanced growth condition", Journal of Process Control, Vol. 14(7), 2004, pp. 717 - 728. [pdf]

I.Y. Smets, J.E. Claes, E.J. November, G. Bastin and J.F. Van Impe, "Optimal adaptive control of (bio)chemical reactors: past, present and future", Journal of Process Control, Vol. 14(7), 2004, pp. 795 - 805. [pdf]

J. de Halleux, C. Prieur, J-M. Coron, B. d'Andréa-Novel, G. Bastin, "Boundary feedback control in networks of open channels", Automatica, Vol.39(8), 2003, pp. 1365-1376. [pdf]

B. David and G. Bastin, "Parameter estimation in nonlinear systems with auto and crosscorrelated noise", Automatica, Vol. 38(1), 2002, pp. 81 - 90. [pdf]

I. Smets, G. Bastin, J. Van Impe "Feedback stabilisation of fed-batch bioreactors for microbial conversion processes with non-monotonic kinetics", Biotechnology Progress, Vol.18(5), 2002, pp. 1116 - 1125. [pdf]

F. Grognard, R. Sepulchre, G. Bastin "Improving the performance of low-gain designs for bounded control of linear systems", Automatica,Vol. 38(10), 2002, pp. 1777-1782. [pdf]

L. Ikonomou, J.C. Drugmand, G. Bastin, Y-J. Schneider, S. Agathos, "Microcarrier culture of lepidopteran cell lines: Implications for growth and recombinant protein production", Biotechnology Progress, Vol. 18(6), 2002, pp. 1345-1355. [pdf]

Full list of publications of G.Bastin


PhD Supervision

Main research topics

  • Nonlinear Control
  • Modelling and Control of Compartmental and Mass-Balance Systems
  • Modelling and Control of Dynamical Network Systems
  • Boundary Control of Hyperbolic (PDE) Systems of Conservation and Balance Laws
  • Application of System Theory in Biology, Robotics, Communication Networks and Environmental Problems

  • Research programmes

    Biotechnology Action Programme (European Commission); Project BAP-0032-B , Advanced Monitoring and Computer Control of Biotechnological Processes, 1986-1989.

    Action de Recherche Concertée (Service de Programmation de la Politique Scientifique - Communauté Française de Belgique) : Control of Nonlinear Multivariable Systems. (Co-direction with Prof. M. Gevers), 1988-1990.

    Interuniversity Attraction Pole (Belgian Federal Scientific Policy) : Modelling, Simulation and Control of Complex Systems, (Co-direction with Prof. M. Crochet et M. Gevers), 1990-1995.

    BRITE/EURAM Programme (European Commission)) : Development of novel intelligent monitoring techniques and optimal adaptive control of fed-batch penicillin fermentations,1992-1995.

    AIR Programme (European Commission)) : Design and scale-up of a bioprocess for the production of natural vanillin from agricultural by-products, 1996 - 1999.

    Regional Government : Design, optimisation, control and validation of a new glycoprotein production process in perfused bioreactors with high cellular densities (Co-direction with Prof. Y-J. Schneider and Prof. S. Agathos), 1999 - 2002.

    Belgian Federal Scientific Policy (SSTC): Sustainable effects of traffic management systems (Co-direction with Prof. G. Campion), 2001-2003.

    Solvay Research Funds (University of Louvain) : Optimal scheduling and on line control of hybrid batch-continuous production processes (Co-direction with Prof. Y. Pochet and Prof. D. Dochain), 2003-2005.

    Industrial contracts

    Modelling and Identification of Hydrological Systems (Ministère des Travaux Publics, Service d' Etudes Hydrologiques), 1986-1988.

    Modelling and Traffic Control on Metro Lines (Société des Transports Inter-communaux de Bruxelles), 1985-1987.

    On-line Monitoring of Biotechnological Processes (SOLVAY, Neder-over-Heembeek), 1987-1988.

    Design of Industrial Adaptive Regulators (Absy, Bruxelles), with the support of IRSIA, 1986-1989.

    Control of Yeast Fermentation Processes for Pharmaceutical Industry (Smith-Kline-Rit, Rixensart), 1988-1989.

    Modelling and Control of Industrial Grinding Processes, with the support of Région Wallonne, 1990-1994 and 1999-2001.

    Modelling of Animal Cell Culture Systems (Smith-Kline-Beecham-Biologicals, Rixensart), 1991-1994.

    Development of flood forecasting models (Région Wallonne, Service d'Etudes Hydrologiques), 1994-2012.

    Modelling and control of an epichlorhydrin production process (SOLVAY, Neder-over-Heembeek), 1996-1999.

    Modelling and control of cooling tables in hot rolling mills (USINOR, Cockerill-Sambre), 2000-2002.

    Automatic prediction of ice conditions on road traffic networks (MACQ-Electronics), 2003-2005.

    Flow and level control in navigable rivers (Siemens and Service Public de Wallonie), 2009-2012.



    PhD Supervision


    Supervision of doctoral dissertations

    D. Dochain : "On-line state and parameter estimation and adaptive control of biotechnological processes", October 1986.

    V. Van Breusegem : "Modelling and feedback control of underground transportation systems", September 1988.

    B. Wery : "Identification of hydrological systems with application to flood forecasting", March 1990.

    C. Delépaut : "Output feedback control of nonlinear systems with state observers", December 1990.

    L. Chen : "Modelling, identifiability and control of complex biotechnological processes", February 1992.

    F. Jarachi : "Predictive control of nonlinear recursive systems", December 1993.

    O. Françoisse : "Adaptive nonlinear control of distributed chemical reactors", December 1993.

    V. Chotteau : "A general modeling methodology for animal cell cultures", July 1995.

    A.M. Guillaume : "Commande adaptative en temps discret de systèmes nonlinéaires continus", May 1996.

    F. Jadot : "Dynamics and robust nonlinear PI control of stirred tank reactors", June 1996.

    P. Carette : "Discarding data to perform more accurate identification of input/output system dynamics", March 1997.

    F. Grognard : "Control of constrained systems : closed loop, open loop and hybrid solutions", October 2001.

    B. David : "Parameter estimation in nonlinear dynamical systems with correlated noise", November 2001.

    J. de Halleux : "Boundary control of quasi-linear hyperbolic systems", September 2004.[pdf]

    V. Guffens : "Compartmental Fluid-Flow Modelling in Packet Switched Networks with Hop-by-Hop Control", December 2005. [pdf]

    A. Provost : "Metabolic design of dynamic bioreaction models", November 2006. [pdf]

    B. Haut : "Modelling and control of road traffic networks described by hyperbolic systems of conservation laws", September 2007. [pdf]

    F. Warichet : "Scheduling of mixed batch-continuous production lines", October 2007. [pdf]

    I. Simeonova : "On-line periodic scheduling of hybrid chemical plants with parallel production lines and shared resources", August 2008. [pdf]

    F. Zamorano : "Metabolic flux analysis of CHO cell cultures", April 2012. [pdf]


    PhD Supervision

    Curriculum Vitae

    Professor at the Center for Systems Engineering and Applied Mechanics (CESAME), Department of Mathematical Engineering, ICTEAM, Université catholique de Louvain.

    1983 - 1989 : Head of the Laboratoire d'Automatique, Dynamique et Analyse des Systèmes.

    1994 - 2000 : Head of the Department of Mathematical Engineering.

    Part-time appointments :

    1984 - 2003 : Professor Fondation Universitaire Luxembourgeoise.

    2001 - 2003 : Associate Professor, Ecole des Mines de Paris.

    Short term appointments :

    1983 : Visiting Professor at Ecole Nationale Supérieure d'Hydraulique de Grenoble (Institut National Polytechnique), France (7 months).

    1985 : Research Fellow at the Systems Engineering Department, Australian National University, Canberra (6 months).

    1989 - 1990 : Invited Research Fellow, Ecole Nationale Supérieure des Mines de Paris, Centre d'Automatique, Fontainebleau, France (6 months)

    1994 : Visiting Fellow, Faculty of Information Science and Engineering, Australian National University, Canberra, Australia (5 months).

    1998 : Associate Professor, Ecole Nationale Supérieure des Mines de Paris, Centre de Robotique, France (6 months)

    2006 : Visiting Professor, Department of Electrical and Electronic Engineering, University of Melbourne, Australia (6 months).

    2010 : Invited Professor, Institut Henri Poincaré, Université Paris VI (3 months).